No Mouse Klick after some time

Hi!

I'm using Version 13.2.5287 on Windows here and  13.xx on MAC at home. Sometimes Mouse control is not possible until I restart Target MAC. (Mouse Movement is possible, but Mouse Klicks not) After Restart it works fine again for some time. 

I have already read some hints about pressing ALT Key or disabeling remote control... but this doesn't work for me.

Any idea? THX!